Sodium–hydrogen antiporter 1

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.^[5]

SLC9A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y4E, 2BEC, 2E30, 2KBV, 2L0E, 2MDF, 2YGG
Identifiers
Aliases	SLC9A1, APNH, NHE-1, NHE1, PPP1R143, LIKNS, Sodium–hydrogen antiporter 1, solute carrier family 9 member A1
External IDs	OMIM: 107310; MGI: 102462; HomoloGene: 20660; GeneCards: SLC9A1; OMA:SLC9A1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 27,098,809 bp[1] End 27,166,981 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 66.25 cM Start 133,097,017 bp[2] End 133,151,013 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of transverse colon oocyte placenta body of stomach stromal cell of endometrium pylorus putamen mucosa of urinary bladder nasal epithelium Top expressed in epithelium of stomach zygote ankle joint pyloric antrum secondary oocyte mucous cell of stomach gastrula granulocyte decidua lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity calcium-dependent protein binding phosphatidylinositol-4,5-bisphosphate binding antiporter activity solute:proton antiporter activity sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential calmodulin binding protein binding molecular adaptor activity protein phosphatase 2B binding sodium:proton antiporter activity potassium:proton antiporter activity Cellular component cytoplasm membrane focal adhesion T-tubule mitochondrion perinuclear region of cytoplasm cation-transporting ATPase complex cell surface apical plasma membrane endoplasmic reticulum membrane raft extracellular exosome lamellipodium integral component of membrane intercalated disc plasma membrane nucleoplasm endoplasmic reticulum membrane integral component of plasma membrane basolateral plasma membrane sarcolemma Biological process regulation of cardiac muscle contraction by calcium ion signaling regulation of sensory perception of pain positive regulation of the force of heart contraction positive regulation of cardiac muscle hypertrophy cellular response to epinephrine stimulus positive regulation of action potential cellular response to mechanical stimulus maintenance of cell polarity cellular response to hypoxia positive regulation of mitochondrial membrane permeability response to muscle stretch proton transmembrane transport cellular sodium ion homeostasis cardiac muscle cell differentiation ion transport positive regulation of cell growth cellular response to insulin stimulus regulation of focal adhesion assembly regulation of cardiac muscle cell membrane potential response to acidic pH cell differentiation regulation of the force of heart contraction cellular response to organic cyclic compound cellular response to acidic pH cation transport negative regulation of apoptotic process regulation of the force of heart contraction by cardiac conduction regulation of pH cardiac muscle cell contraction neuron death hyaluronan catabolic process response to organic cyclic compound sodium ion transport regulation of intracellular pH positive regulation of intracellular signal transduction regulation of stress fiber assembly positive regulation of calcineurin-NFAT signaling cascade protein complex oligomerization sodium ion import across plasma membrane positive regulation of apoptotic process cellular response to antibiotic positive regulation of calcium:sodium antiporter activity cell migration positive regulation of transcription by RNA polymerase II cellular response to electrical stimulus potassium ion transmembrane transport transmembrane transport transport cellular response to cold sodium ion export across plasma membrane anion transmembrane transport sodium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6548 20544 Ensembl ENSG00000090020 ENSMUSG00000028854 UniProt P19634 Q61165 RefSeq (mRNA) NM_003047 NM_016981 NM_001358455 RefSeq (protein) NP_003038 NP_058677 NP_001345384 Location (UCSC) Chr 1: 27.1 – 27.17 Mb Chr 4: 133.1 – 133.15 Mb PubMed search [3] [4]
Wikidata
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Function

The Na⁺/H⁺ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.^[6]

Interactions

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II^[7] and CHP.^[8][9][10] It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.^[11]