Sodium-hydrogen antiporter 3 regulator 1

Sodium-hydrogen antiporter 3 regulator 1 (SLC9A3R1) is a human protein. It is a regulator of Sodium-hydrogen antiporter 3 and is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed^[5] to interact via long-range allostery, involving significant protein dynamics.

SLC9A3R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G9O, 1GQ4, 1GQ5, 1I92, 2D10, 2JXO, 2KJD, 2KRG, 2M0T, 2M0U, 2M0V, 2OZF, 4JL7, 4LMM, 4MPA, 4N6X, 4PQW, 4Q3H
Identifiers
Aliases	SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2, Sodium-hydrogen antiporter 3 regulator 1, SLC9A3 regulator 1
External IDs	OMIM: 604990; MGI: 1349482; HomoloGene: 3137; GeneCards: SLC9A3R1; OMA:SLC9A3R1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,748,628 bp[1] End 74,769,353 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,054,167 bp[2] End 115,072,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte olfactory zone of nasal mucosa mucosa of transverse colon right adrenal gland mucosa of ileum right adrenal cortex right lobe of liver jejunal mucosa left adrenal cortex minor salivary glands Top expressed in jejunum retinal pigment epithelium yolk sac ileum duodenum left lobe of liver granulocyte right kidney left colon primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein self-association growth factor receptor binding dopamine receptor binding beta-catenin binding beta-2 adrenergic receptor binding phosphatase binding signaling receptor binding molecular adaptor activity protein binding protein-containing complex binding protein domain specific binding chloride channel regulator activity PDZ domain binding myosin II binding protein N-terminus binding Cellular component brush border membrane vesicle endomembrane system nucleus cell periphery cell projection actin cytoskeleton perinuclear region of cytoplasm apical part of cell ruffle stereocilium extracellular exosome membrane membrane raft microvillus membrane cytoplasm microvillus stereocilium tip apical plasma membrane sperm midpiece filopodium plasma membrane intracellular membrane-bounded organelle Biological process negative regulation of cell population proliferation regulation of protein kinase activity positive regulation of intrinsic apoptotic signaling pathway regulation of cell size actin cytoskeleton organization renal absorption regulation of sodium:proton antiporter activity phospholipase C-activating dopamine receptor signaling pathway microvillus assembly bile acid secretion cAMP-mediated signaling establishment of Golgi localization hearing renal phosphate ion absorption gland morphogenesis negative regulation of cell motility negative regulation of protein kinase B signaling auditory receptor cell stereocilium organization negative regulation of phosphatidylinositol 3-kinase signaling establishment of epithelial cell apical/basal polarity negative regulation of ERK1 and ERK2 cascade adenylate cyclase-activating dopamine receptor signaling pathway regulation of excretion cellular phosphate ion homeostasis negative regulation of mitotic cell cycle glutathione transport renal sodium ion transport negative regulation of sodium:proton antiporter activity negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of cell migration regulation of cell shape Wnt signaling pathway negative regulation of sodium ion transport nuclear migration protein localization to plasma membrane positive regulation of ion transmembrane transport protein-containing complex assembly negative regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9368 26941 Ensembl ENSG00000109062 ENSMUSG00000020733 UniProt O14745 P70441 RefSeq (mRNA) NM_004252 NM_012030 RefSeq (protein) NP_004243 NP_036160 Location (UCSC) Chr 17: 74.75 – 74.77 Mb Chr 11: 115.05 – 115.07 Mb PubMed search [3] [4]
Wikidata
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Mechanism

Members of the ezrin (VIL2; MIM 123900)-radixin (RDX; MIM 179410)-moesin (MSN; MIM 309845) (ERM) protein family are highly concentrated in the apical aspect of polarized epithelial cells. These cells are studded with microvilli containing bundles of actin filaments, which must attach to the membrane to assemble and maintain the microvilli. The ERM proteins, together with merlin, the NF2 (MIM 607379) gene product, are thought to be linkers between integral membrane and cytoskeletal proteins, and they bind directly to actin in vitro. Actin cytoskeleton reorganization requires the activation of a sodium/hydrogen exchanger (SLC9A3; MIM 182307). SLC9A3R1 is an ERM-binding protein.[supplied by OMIM]^[6]

Interactions

Sodium-hydrogen antiporter 3 regulator 1 has been shown to interact with:

• ADRB2,^[7][8][9]
• Beta-catenin,^[10]
• CFTR,^{[8][11][12][13][14][15][16]}
• GNAQ,^[17]
• OPRK1,^[18][19]
• PAG1,^[20]
• PDGFRA,^[21]
• PDGFRB,^[21]
• PDZK1,^[22]
• PTH1R,^[23]
• SLC4A8,^[11][24]
• YAP1,^[25] and
• EZR^[20][26]

See also

• Cystic fibrosis transmembrane conductance regulator
• Ezrin
• Moesin
• Neutron spin echo
• Radixin
• Solute carrier family