SLC9B2

Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene.^[5]

SLC9B2
Identifiers
Aliases	SLC9B2, NHA2, NHE10, NHEDC2, solute carrier family 9 member B2
External IDs	OMIM: 611789; MGI: 2140077; HomoloGene: 45381; GeneCards: SLC9B2; OMA:SLC9B2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 103,019,868 bp[1] End 103,085,829 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 135,013,461 bp[2] End 135,051,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve prefrontal cortex Achilles tendon tibia Brodmann area 9 cerebellar hemisphere right frontal lobe liver right hemisphere of cerebellum islet of Langerhans Top expressed in body of femur membranous bone Dermatocranium mandible maxilla upper lip embryo embryo epithelium of stomach tibiofemoral joint More reference expression data BioGPS n/a
Gene ontology Molecular function solute:proton antiporter activity antiporter activity monovalent cation:proton antiporter activity lithium:proton antiporter activity sodium:proton antiporter activity identical protein binding Cellular component integral component of membrane membrane mitochondrion mitochondrial inner membrane endosome membrane basolateral plasma membrane synaptic vesicle membrane sperm principal piece plasma membrane mitochondrial membranes intracellular vesicle endosome apical plasma membrane cell junction cytoplasmic vesicle cell projection synapse cilium motile cilium Biological process proton transmembrane transport ion transmembrane transport cation transport ion transport positive regulation of osteoclast development transmembrane transport flagellated sperm motility sodium ion transmembrane transport regulation of insulin secretion involved in cellular response to glucose stimulus clathrin-dependent endocytosis sodium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 133308 97086 Ensembl ENSG00000164038 ENSMUSG00000037994 UniProt Q86UD5 Q5BKR2 RefSeq (mRNA) NM_001300754 NM_001300756 NM_178833 NM_178877 RefSeq (protein) NP_001287683 NP_001287685 NP_849155 NP_001357128 NP_001357129 NP_001357130 NP_001357131 NP_001357132 NP_001357133 NP_001357134 NP_001357135 NP_001357136 NP_849208 Location (UCSC) Chr 4: 103.02 – 103.09 Mb Chr 3: 135.01 – 135.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Sodium–hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux.^[6]