SLFN11

Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene.^[5][6]

SLFN11
Identifiers
Aliases	SLFN11, SLFN8/9, schlafen family member 11
External IDs	OMIM: 614953; MGI: 2672859; HomoloGene: 89175; GeneCards: SLFN11; OMA:SLFN11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,350,305 bp[1] End 35,373,701 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 82,892,984 bp[2] End 82,911,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon sural nerve bone marrow cells right lobe of thyroid gland left uterine tube left lobe of thyroid gland granulocyte appendix upper lobe of left lung Top expressed in spleen granulocyte thymus bone marrow embryo ovary embryo zone of skin jejunum liver More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA binding nucleotide binding ATP binding RNA binding protein binding ATPase activity helicase activity hydrolase activity Cellular component aggresome nucleus nucleoplasm cytosol site of DNA damage chromosome Biological process negative regulation of G1/S transition of mitotic cell cycle defense response to virus immune system process negative regulation of DNA replication positive regulation of cell death replication fork arrest cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91607 276950 Ensembl ENSG00000172716 ENSMUSG00000035208 UniProt Q7Z7L1 B1ARD8 RefSeq (mRNA) NM_001104587 NM_001104588 NM_001104589 NM_001104590 NM_152270 NM_001376007 NM_001376008 NM_001376009 NM_001376010 NM_001376011 NM_001376012 NM_001387158 NM_001387159 NM_001387160 NM_001387161 NM_001387162 NM_001387163 NM_001167743 NM_181545 RefSeq (protein) NP_001098057 NP_001098058 NP_001098059 NP_001098060 NP_689483 NP_001362936 NP_001362937 NP_001362938 NP_001362939 NP_001362940 NP_001362941 NP_001161215 NP_853523 Location (UCSC) Chr 17: 35.35 – 35.37 Mb Chr 11: 82.89 – 82.91 Mb PubMed search [3] [4]
Wikidata
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