SLFN14

Schlafen family member 14 is a protein that in humans is encoded by the SLFN14 gene. ^[5]

SLFN14
Identifiers
Aliases	SLFN14, BDPLT20, schlafen family member 14
External IDs	OMIM: 614958; MGI: 2684866; HomoloGene: 19082; GeneCards: SLFN14; OMA:SLFN14 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,543,985 bp[1] End 35,560,819 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 83,165,936 bp[2] End 83,177,552 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte bone marrow cells blood granulocyte lymph node spleen right lung right uterine tube appendix placenta Top expressed in bone marrow spleen embryo ovary genital tubercle thoracic segment of trunk heart stomach neural tube liver More reference expression data BioGPS n/a
Gene ontology Molecular function ribosome binding ATP binding endoribonuclease activity nuclease activity hydrolase activity endonuclease activity nucleotide binding Cellular component cytoplasm nucleus Biological process rRNA catabolic process cellular response to magnesium ion cellular response to manganese ion mRNA catabolic process RNA phosphodiester bond hydrolysis, endonucleolytic platelet maturation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 342618 237890 Ensembl ENSG00000236320 ENSMUSG00000082101 UniProt P0C7P3 V9GXG1 RefSeq (mRNA) NM_001129820 NM_001166028 RefSeq (protein) NP_001123292 NP_001159500 Location (UCSC) Chr 17: 35.54 – 35.56 Mb Chr 11: 83.17 – 83.18 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016].