SLIT3

Slit homolog 3 protein is a protein that in humans is encoded by the SLIT3 gene.^[5][6][7]

SLIT3
Identifiers
Aliases	SLIT3, MEGF5, SLIL2, SLIT1, Slit-3, slit2, slit guidance ligand 3
External IDs	OMIM: 603745; MGI: 1315202; HomoloGene: 2303; GeneCards: SLIT3; OMA:SLIT3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q34-q35.1 Start 168,661,733 bp[1] End 169,301,139 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 35,012,051 bp[2] End 35,599,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery popliteal artery tibial arteries saphenous vein gallbladder cardiac muscle tissue of right atrium vena cava subcutaneous adipose tissue left coronary artery right auricle of heart Top expressed in umbilical cord gastrula genital tubercle paramesonephric duct ascending aorta tail of embryo lip superior cervical ganglion skin of external ear cardiac muscle tissue of atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Roundabout binding calcium ion binding heparin binding Cellular component extracellular region mitochondrion extracellular space Biological process negative regulation of chemokine-mediated signaling pathway chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration cell differentiation negative chemotaxis Roundabout signaling pathway negative regulation of gene expression nervous system development multicellular organism development cellular response to hormone stimulus negative regulation of cell growth response to cortisol apoptotic process involved in luteolysis animal organ morphogenesis axon extension involved in axon guidance negative regulation of cell population proliferation axon guidance aortic valve morphogenesis atrioventricular valve morphogenesis ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6586 20564 Ensembl ENSG00000184347 ENSMUSG00000056427 UniProt O75094 Q9WVB4 RefSeq (mRNA) NM_003062 NM_001271946 NM_011412 RefSeq (protein) NP_001258875 NP_003053 NP_035542 Location (UCSC) Chr 5: 168.66 – 169.3 Mb Chr 11: 35.01 – 35.6 Mb PubMed search [3] [4]
Wikidata
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