SMARCD2

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein in humans that is encoded by the SMARCD2 gene.^[5][6][7]

SMARCD2
Identifiers
Aliases	SMARCD2, BAF60B, CRACD2, Rsc6p, PRO2451, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2, SGD2
External IDs	OMIM: 601736; MGI: 1933621; HomoloGene: 20671; GeneCards: SMARCD2; OMA:SMARCD2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,832,081 bp[1] End 63,843,065 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 106,154,005 bp[2] End 106,163,798 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg body of pancreas gastric mucosa body of stomach minor salivary glands left uterine tube ectocervix cerebellar hemisphere tibial nerve Top expressed in Ileal epithelium conjunctival fornix renal corpuscle medullary collecting duct hair follicle Paneth cell lacrimal gland condyle fossa internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleosomal DNA binding transcription coactivator activity protein binding Cellular component SWI/SNF complex nucleus nucleoplasm protein-containing complex Biological process regulation of transcription by RNA polymerase II chromatin remodeling nucleosome disassembly regulation of transcription, DNA-templated transcription, DNA-templated chromatin organization positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6603 83796 Ensembl ENSG00000108604 ENSMUSG00000078619 UniProt Q92925 Q99JR8 RefSeq (mRNA) NM_001098426 NM_003077 NM_001330439 NM_001330440 NM_001130187 NM_031878 RefSeq (protein) NP_001091896 NP_001317368 NP_001317369 NP_001123659 NP_114084 Location (UCSC) Chr 17: 63.83 – 63.84 Mb Chr 11: 106.15 – 106.16 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.^[7]