SMCP

This article is about the human gene. For the communication standard, see Standard Marine Communication Phrases. For the video game, see Sonic Mega Collection § Sonic Mega Collection Plus. For the company, see SM Culture Partners.

Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene.^[5][6]

SMCP
Identifiers
Aliases	SMCP, HSMCSGEN1, MCS, MCSP, sperm mitochondria associated cysteine rich protein
External IDs	OMIM: 601148; MGI: 96945; HomoloGene: 136205; GeneCards: SMCP; OMA:SMCP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 152,878,322 bp[1] End 152,885,047 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 92,491,174 bp[2] End 92,496,304 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis testicle buccal mucosa cell tail of epididymis gonad caput epididymis corpus epididymis rhombencephalon Top expressed in seminiferous tubule spermatid spermatocyte right kidney proximal tubule epithelium of small intestine human kidney migratory enteric neural crest cell ileum zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytoplasm mitochondrial membranes mitochondrion membrane Biological process flagellated sperm motility penetration of zona pellucida single fertilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4184 17235 Ensembl ENSG00000163206 ENSMUSG00000074435 UniProt P49901 P15265 RefSeq (mRNA) NM_030663 NM_008574 RefSeq (protein) NP_109588 NP_032600 Location (UCSC) Chr 1: 152.88 – 152.89 Mb Chr 3: 92.49 – 92.5 Mb PubMed search [3] [4]
Wikidata
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Function

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.^[6]