SMOX

Spermine oxidase is an enzyme that in humans is encoded by the SMOX gene.^[5][6][7]

SMOX
Identifiers
Aliases	SMOX, C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO, spermine oxidase
External IDs	OMIM: 615854; MGI: 2445356; HomoloGene: 69268; GeneCards: SMOX; OMA:SMOX - orthologs
EC number	1.5.3.16
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 4,120,980 bp[1] End 4,187,747 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 131,491,496 bp[2] End 131,525,922 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala C1 segment putamen substantia nigra hypothalamus nucleus accumbens monocyte cartilage tissue caudate nucleus Region I of hippocampus proper Top expressed in triceps brachii muscle sternocleidomastoid muscle vastus lateralis muscle knee joint gastrocnemius muscle granulocyte medial head of gastrocnemius muscle skeletal muscle tissue fetal liver hematopoietic progenitor cell molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity polyamine oxidase activity oxidoreductase activity norspermine:oxygen oxidoreductase activity spermine:oxygen oxidoreductase (spermidine-forming) activity Cellular component cytosol nucleus cytoplasm nucleoplasm nuclear membrane intracellular membrane-bounded organelle Biological process polyamine catabolic process spermine catabolic process polyamine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54498 228608 Ensembl ENSG00000088826 ENSMUSG00000027333 UniProt Q9NWM0 Q99K82 RefSeq (mRNA) NM_001270691 NM_175839 NM_175840 NM_175841 NM_175842 NM_019025 NM_001177833 NM_001177834 NM_001177835 NM_001177836 NM_001177837 NM_001177838 NM_001177839 NM_001177840 NM_145533 RefSeq (protein) NP_001257620 NP_787033 NP_787034 NP_787035 NP_787036 NP_001171304 NP_001171305 NP_001171306 NP_001171307 NP_001171308 NP_001171309 NP_001171310 NP_001171311 NP_663508 Location (UCSC) Chr 20: 4.12 – 4.19 Mb Chr 2: 131.49 – 131.53 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.^[7]