SMPD2

Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.^[5][6]

SMPD2
Identifiers
Aliases	SMPD2, ISC1, NSMASE, NSMASE1, sphingomyelin phosphodiesterase 2
External IDs	OMIM: 603498; MGI: 1278330; HomoloGene: 31129; GeneCards: SMPD2; OMA:SMPD2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 109,440,724 bp[1] End 109,443,919 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 41,361,638 bp[2] End 41,366,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left testis right testis mucosa of transverse colon olfactory zone of nasal mucosa sperm gingival epithelium bronchial epithelial cell granulocyte skin of abdomen Top expressed in right kidney proximal tubule yolk sac human kidney saccule jejunum retinal pigment epithelium granulocyte duodenum neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingomyelin phosphodiesterase activity metal ion binding hydrolase activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure caveola Biological process positive regulation of ceramide biosynthetic process intracellular signal transduction lipid metabolism ceramide biosynthetic process response to mechanical stimulus sphingomyelin metabolic process sphingolipid metabolic process sphingomyelin catabolic process glycosphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6610 20598 Ensembl ENSG00000135587 ENSMUSG00000019822 UniProt O60906 O70572 RefSeq (mRNA) NM_003080 NM_009213 RefSeq (protein) NP_003071 NP_033239 Location (UCSC) Chr 6: 109.44 – 109.44 Mb Chr 10: 41.36 – 41.37 Mb PubMed search [3] [4]
Wikidata
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