SMPD3

Neutral Sphingomyelinase2 is an enzyme that in humans is encoded by the SMPD3 gene.^[5][6]

SMPD3
Identifiers
Aliases	SMPD3, NSMASE2, sphingomyelin phosphodiesterase 3
External IDs	OMIM: 605777; MGI: 1927578; HomoloGene: 10260; GeneCards: SMPD3; OMA:SMPD3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,358,327 bp[1] End 68,448,508 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,979,180 bp[2] End 107,064,620 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia duodenum periodontal fiber thymus jejunal mucosa ganglionic eminence mucosa of transverse colon putamen right hemisphere of cerebellum rectum Top expressed in membranous bone Dermatocranium calvaria mandible maxilla lumbar spinal ganglion olfactory tubercle long bone body of femur molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingomyelin phosphodiesterase activity metal ion binding hydrolase activity protein binding neutral sphingomyelin phosphodiesterase activity phospholipase activity Cellular component Golgi apparatus membrane Golgi membrane Golgi cis cisterna plasma membrane cytoplasm Biological process positive regulation of ceramide biosynthetic process lipid metabolism multicellular organism development sphingomyelin catabolic process peptide hormone secretion hematopoietic progenitor cell differentiation cell cycle positive regulation of exosomal secretion sphingomyelin metabolic process sphingolipid metabolic process skeletal system development endochondral ossification chondrocyte development regulation of leukocyte migration bone mineralization BMP signaling pathway multicellular organism growth protein kinase B signaling cartilage development protein homooligomerization bone development regulation of cartilage development cellular response to redox state bone growth cellular response to peptide ossification regulation of protein phosphorylation chondrocyte development involved in endochondral bone morphogenesis ceramide metabolic process glycosphingolipid metabolic process signal transduction polysaccharide transport lung development collagen metabolic process cellular response to reactive oxygen species positive regulation of mitotic nuclear division platelet-derived growth factor receptor signaling pathway lung alveolus development positive regulation of smooth muscle cell proliferation respiratory system development cellular response to hydrogen peroxide G1 to G0 transition cellular response to magnesium ion cellular response to tumor necrosis factor DNA biosynthetic process extracellular matrix assembly sphingolipid mediated signaling pathway dentinogenesis mitotic nuclear division cellular response to oxidised low-density lipoprotein particle stimulus regulation of hyaluronan biosynthetic process negative regulation of hyaluronan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55512 58994 Ensembl ENSG00000103056 ENSMUSG00000031906 UniProt Q9NY59 Q9JJY3 RefSeq (mRNA) NM_018667 NM_021491 RefSeq (protein) NP_061137 NP_067466 Location (UCSC) Chr 16: 68.36 – 68.45 Mb Chr 8: 106.98 – 107.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse