SNAG1

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.^[5][6][7]

SNX18
Identifiers
Aliases	SNX18, SH3PX2, SH3PXD3B, SNAG1, sorting nexin 18
External IDs	MGI: 2137642; HomoloGene: 14164; GeneCards: SNX18; OMA:SNX18 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 54,517,759 bp[1] End 54,546,586 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 113,728,715 bp[2] End 113,755,100 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell pancreatic ductal cell skin of arm germinal epithelium amniotic fluid palpebral conjunctiva endothelial cell synovial membrane saphenous vein trabecular bone Top expressed in cumulus cell medullary collecting duct ascending aorta external carotid artery renal corpuscle aortic valve tunica media of zone of aorta internal carotid artery secondary oocyte sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding lipid binding Cellular component membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane endosome membrane extracellular exosome cytoplasmic vesicle membrane endomembrane system clathrin-coated vesicle cytoplasmic vesicle endosome Biological process cleavage furrow formation cell division endosomal transport positive regulation of GTPase activity protein transport cell cycle endocytosis mitotic cytokinesis mitotic cell cycle transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112574 170625 Ensembl ENSG00000178996 ENSMUSG00000042364 UniProt Q96RF0 Q91ZR2 Q8C788 RefSeq (mRNA) NM_052870 NM_001102575 NM_001145427 NM_130796 RefSeq (protein) NP_001096045 NP_001138899 NP_443102 NP_570614 Location (UCSC) Chr 5: 54.52 – 54.55 Mb Chr 13: 113.73 – 113.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.^[7]