SNTB2

Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene.^[5][6][7]

SNTB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VRF
Identifiers
Aliases	SNTB2, D16S2531E, EST25263, SNT2B2, SNT3, SNTL, syntrophin beta 2
External IDs	OMIM: 600027; MGI: 101771; HomoloGene: 4911; GeneCards: SNTB2; OMA:SNTB2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,187,147 bp[1] End 69,309,052 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.38 cM Start 107,662,382 bp[2] End 107,746,346 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia parietal pleura nipple synovial joint retinal pigment epithelium vena cava skin of hip lactiferous duct pericardium urethra Top expressed in lumbar spinal ganglion gastrula aortic valve ascending aorta epithelium of lens calvaria decidua endothelial cell of lymphatic vessel mesenteric lymph nodes retinal pigment epithelium More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 6645 20650 Ensembl ENSG00000168807 ENSG00000260873 ENSMUSG00000041308 UniProt Q13425 Q61235 RefSeq (mRNA) NM_130845 NM_006750 NM_009229 NM_001368316 RefSeq (protein) NP_006741 NP_006741.1 NP_033255 NP_001355245 Location (UCSC) Chr 16: 69.19 – 69.31 Mb Chr 8: 107.66 – 107.75 Mb PubMed search [3] [4]
Wikidata
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Function

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes.^[7]

Interactions

SNTB2 has been shown to interact with ABCA1.^[8]