SNX1

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.^[5] SNX1 is a component of the retromer complex.^[6][7]

SNX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I4K, 4FZS
Identifiers
Aliases	SNX1, HsT17379, VPS5, sorting nexin 1
External IDs	OMIM: 601272; MGI: 1928395; HomoloGene: 99716; GeneCards: SNX1; OMA:SNX1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 64,094,123 bp[1] End 64,146,090 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 65,995,415 bp[2] End 66,033,869 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right adrenal gland right adrenal cortex left adrenal gland monocyte upper lobe of left lung ectocervix C1 segment left adrenal cortex Top expressed in spermatocyte gastrula spermatid decidua blastocyst saccule morula yolk sac lens ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding identical protein binding protein heterodimerization activity transferrin receptor binding lipid binding cadherin binding Cellular component cytoplasm cytosol Golgi apparatus cell projection early endosome membrane membrane retromer, tubulation complex intracellular membrane-bounded organelle retromer complex early endosome endosome membrane lamellipodium extrinsic component of membrane vesicle lysosome endosome protein-containing complex Biological process positive regulation of protein catabolic process vesicle organization early endosome to Golgi transport receptor internalization endosomal transport retrograde transport, endosome to Golgi protein transport intracellular protein transport lamellipodium morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6642 56440 Ensembl ENSG00000028528 ENSMUSG00000032382 UniProt Q13596 Q9WV80 RefSeq (mRNA) NM_001242933 NM_003099 NM_148955 NM_152826 NM_019727 RefSeq (protein) NP_001229862 NP_003090 NP_683758 NP_062701 Location (UCSC) Chr 15: 64.09 – 64.15 Mb Chr 9: 66 – 66.03 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.^[8]