SNX17

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.^[5][6][7]

SNX17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FOG, 3LUI, 4GXB, 4TKN
Identifiers
Aliases	SNX17, sorting nexin 17
External IDs	OMIM: 605963; MGI: 2387801; HomoloGene: 8838; GeneCards: SNX17; OMA:SNX17 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,370,496 bp[1] End 27,377,535 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,350,571 bp[2] End 31,356,487 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right adrenal gland right adrenal cortex monocyte left adrenal gland left adrenal cortex anterior pituitary stromal cell of endometrium right coronary artery spleen Top expressed in medial ganglionic eminence renal corpuscle internal carotid artery external carotid artery epithelium of lens Paneth cell vestibular membrane of cochlear duct Rostral migratory stream endocardial cushion median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function low-density lipoprotein particle receptor binding protein C-terminus binding protein binding phosphatidylinositol binding signaling receptor binding lipid binding Cellular component cytosol endosome Golgi apparatus membrane intracellular membrane-bounded organelle early endosome endosome membrane cytoplasmic vesicle membrane cytoplasm cytoplasmic vesicle protein-containing complex Biological process regulation of endocytosis cardiac septum development cholesterol catabolic process receptor-mediated endocytosis coronary vasculature development endosomal transport aorta development protein transport signal transduction intracellular protein transport endocytic recycling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9784 266781 Ensembl ENSG00000115234 ENSMUSG00000029146 UniProt Q15036 Q8BVL3 RefSeq (mRNA) NM_001267059 NM_001267060 NM_001267061 NM_014748 NM_153680 RefSeq (protein) NP_001253988 NP_001253989 NP_001253990 NP_055563 NP_710147 Location (UCSC) Chr 2: 27.37 – 27.38 Mb Chr 5: 31.35 – 31.36 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.^[7]

Interactions

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8^[5]