SNX4

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.^[5][6]

SNX4
Identifiers
Aliases	SNX4, ATG24B, sorting nexin 4
External IDs	OMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.2 Start 125,446,650 bp[1] End 125,520,202 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 33,071,812 bp[2] End 33,120,639 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa Achilles tendon kidney tubule ganglionic eminence ventricular zone islet of Langerhans duodenum Epithelium of choroid plexus tendon of biceps brachii Top expressed in atrioventricular valve left lung lobe endocardial cushion sciatic nerve granulocyte yolk sac vestibular sensory epithelium ureter primitive streak zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding transferrin receptor binding lipid binding Cellular component cytoplasm extrinsic component of membrane endosome early endosome membrane membrane plasma membrane SNARE complex cytoplasmic dynein complex protein-containing complex early endosome Biological process endocytosis vesicle organization endocytic recycling protein transport positive regulation of histamine secretion by mast cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8723 69150 Ensembl ENSG00000114520 ENSMUSG00000022808 UniProt O95219 Q91YJ2 RefSeq (mRNA) NM_003794 NM_080557 RefSeq (protein) NP_003785 NP_542124 Location (UCSC) Chr 3: 125.45 – 125.52 Mb Chr 16: 33.07 – 33.12 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.^[6]

Interactions

SNX4 has been shown to interact with BIN1.^[7]