SNX5

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.^[5][6][7]

SNX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SYS
Identifiers
Aliases	SNX5, sorting nexin 5
External IDs	OMIM: 605937; MGI: 1916428; HomoloGene: 40944; GeneCards: SNX5; OMA:SNX5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.23 Start 17,941,597 bp[1] End 17,968,980 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G1|2 70.98 cM Start 144,092,043 bp[2] End 144,112,826 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland ventricular zone Achilles tendon rectum gonad spleen corpus epididymis secondary oocyte left ovary Top expressed in stroma of bone marrow tail of embryo abdominal wall epiblast Gonadal ridge mandibular prominence dermis efferent ductule migratory enteric neural crest cell maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dynactin binding protein binding phosphatidylinositol binding protein heterodimerization activity lipid binding cadherin binding phosphatidylinositol-5-phosphate binding D1 dopamine receptor binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-3,5-bisphosphate binding Cellular component cytoplasm endosome cell projection early endosome membrane retromer, tubulation complex membrane ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane extrinsic component of endosome membrane tubular endosome retromer complex early endosome phagocytic cup cytoplasmic vesicle membrane macropinocytic cup cytoplasmic vesicle cytosol brush border intracellular anatomical structure Biological process endocytosis vesicle organization retrograde transport, endosome to Golgi protein transport pinocytosis intracellular protein transport regulation of macroautophagy epidermal growth factor catabolic process positive regulation of renal sodium excretion negative regulation of blood pressure Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27131 69178 Ensembl ENSG00000089006 ENSMUSG00000027423 UniProt Q9Y5X3 Q5QPE4 Q9D8U8 RefSeq (mRNA) NM_152227 NM_001282454 NM_014426 NM_001199188 NM_024225 RefSeq (protein) NP_001269383 NP_055241 NP_689413 NP_001186117 NP_077187 Location (UCSC) Chr 20: 17.94 – 17.97 Mb Chr 2: 144.09 – 144.11 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex,^[6] which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.^[7]

Interactions

SNX5 has been shown to interact with FANCA.^[5]