SOAT2

Not to be confused with Acetyl-Coenzyme A acetyltransferase.

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.^[5]

SOAT2
Identifiers
Aliases	SOAT2, ACACT2, ACAT2, ARGP2, sterol O-acyltransferase 2
External IDs	OMIM: 601311; MGI: 1332226; HomoloGene: 68355; GeneCards: SOAT2; OMA:SOAT2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,103,486 bp[1] End 53,124,535 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.33 cM Start 102,058,961 bp[2] End 102,071,904 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa testicle gonad duodenum spleen right lobe of liver gastric mucosa tibial nerve thoracic aorta ascending aorta Top expressed in yolk sac jejunum intestinal villus Ileal epithelium duodenum left lobe of liver perirhinal cortex entorhinal cortex choroid plexus of fourth ventricle primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity cholesterol binding O-acyltransferase activity fatty-acyl-CoA binding sterol O-acyltransferase activity acyltransferase activity cholesterol O-acyltransferase activity Cellular component membrane integral component of membrane brush border endoplasmic reticulum endoplasmic reticulum membrane Biological process very-low-density lipoprotein particle assembly steroid metabolic process macrophage derived foam cell differentiation intestinal cholesterol absorption cholesterol efflux lipid metabolism cholesterol esterification cholesterol homeostasis cholesterol metabolic process low-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8435 223920 Ensembl ENSG00000167780 ENSMUSG00000023045 UniProt O75908 O88908 RefSeq (mRNA) NM_003578 NM_146064 RefSeq (protein) NP_003569 NP_666176 Location (UCSC) Chr 12: 53.1 – 53.12 Mb Chr 15: 102.06 – 102.07 Mb PubMed search [3] [4]
Wikidata
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Function

See also: Long-chain fatty acid and Fatty acyl-CoA esters

This gene is a member of a small family of Acyl-CoA:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.^[5]