Suppressor of cytokine signaling 1

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.^[5][6] SOCS1 orthologs^[7] have been identified in several mammals for which complete genome data are available.

SOCS1
Identifiers
Aliases	SOCS1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, suppressor of cytokine signaling 1, TIP-3, AISIMD
External IDs	OMIM: 603597; MGI: 1354910; HomoloGene: 2776; GeneCards: SOCS1; OMA:SOCS1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.13 Start 11,254,417 bp[1] End 11,256,204 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 5.81 cM Start 10,600,104 bp[2] End 10,603,400 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell sperm canal of the cervix testicle spleen appendix superficial temporal artery granulocyte lymph node ectocervix Top expressed in thymus granulocyte submandibular gland mesenteric lymph nodes zygote embryo morula secondary oocyte bone marrow vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor receptor binding protein kinase inhibitor activity protein binding protein kinase binding kinase inhibitor activity 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm cytosol cytoplasmic vesicle nucleus nucleoplasm cytoplasmic ribonucleoprotein granule phosphatidylinositol 3-kinase complex Biological process intracellular signal transduction regulation of interferon-gamma-mediated signaling pathway protein ubiquitination regulation of growth negative regulation of signal transduction negative regulation of protein kinase activity negative regulation of receptor signaling pathway via JAK-STAT positive regulation of regulatory T cell differentiation interleukin-7-mediated signaling pathway regulation of protein phosphorylation cytokine-mediated signaling pathway negative regulation of tyrosine phosphorylation of STAT protein positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation negative regulation of insulin receptor signaling pathway receptor signaling pathway via JAK-STAT regulation of activation of Janus kinase activity negative regulation of kinase activity regulation of tyrosine phosphorylation of STAT protein regulation of phosphatidylinositol 3-kinase activity fat cell differentiation regulation of receptor signaling pathway via JAK-STAT phosphatidylinositol phosphate biosynthetic process cellular response to amino acid stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8651 12703 Ensembl ENSG00000185338 ENSMUSG00000038037 UniProt O15524 O35716 RefSeq (mRNA) NM_003745 NM_001271603 NM_009896 RefSeq (protein) NP_003736 NP_001258532 NP_034026 Location (UCSC) Chr 16: 11.25 – 11.26 Mb Chr 16: 10.6 – 10.6 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3, erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.^[8]

Several recent viral studies have shown that viral genes, such as Tax gene product (Tax), encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.^[9]

Interactions

The suppressor of cytokine signaling 1 has been shown to interact with:

• Tax,^[9]
• CD117,^[10]
• Colony stimulating factor 1 receptor^[11]
• Growth hormone receptor,^[12]
• IRS2,^[13]
• Janus kinase 2,^{[14][15][16][17][18][19]} and
• TEC.^[20]

See also

• SOCS
• JAK-STAT signaling pathway