SOCS2

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.^[5][6][7]

SOCS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C9W, 4JGH, 5BO4
Identifiers
Aliases	SOCS2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2
External IDs	OMIM: 605117; MGI: 1201787; HomoloGene: 2880; GeneCards: SOCS2; OMA:SOCS2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 93,569,814 bp[1] End 93,583,487 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 49.35 cM Start 95,221,224 bp[2] End 95,253,042 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte canal of the cervix vena cava body of uterus myometrium seminal vesicula Epithelium of choroid plexus ectocervix prostate pituitary gland Top expressed in cumulus cell Ileal epithelium olfactory epithelium vestibular membrane of cochlear duct left lung lobe vestibular sensory epithelium stria vascularis Gonadal ridge right lung interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor receptor binding protein kinase inhibitor activity JAK pathway signal transduction adaptor activity protein binding growth hormone receptor binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm cytosol phosphatidylinositol 3-kinase complex Biological process receptor signaling pathway via JAK-STAT response to estradiol intracellular signal transduction negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of apoptotic process negative regulation of insulin receptor signaling pathway cellular response to hormone stimulus growth hormone receptor signaling pathway regulation of signal transduction regulation of cell growth protein ubiquitination regulation of growth negative regulation of signal transduction negative regulation of receptor signaling pathway via JAK-STAT positive regulation of signal transduction lactation regulation of multicellular organism growth negative regulation of multicellular organism growth post-translational protein modification positive regulation of neuron differentiation mammary gland alveolus development interleukin-7-mediated signaling pathway regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8835 216233 Ensembl ENSG00000120833 ENSMUSG00000020027 UniProt O14508 O35717 RefSeq (mRNA) NM_001270467 NM_001270468 NM_001270469 NM_001270470 NM_001270471 NM_003877 NM_001168655 NM_001168656 NM_001168657 NM_007706 RefSeq (protein) NP_001257396 NP_001257397 NP_001257398 NP_001257399 NP_001257400 NP_003868 NP_001162126 NP_001162127 NP_001162128 NP_031732 Location (UCSC) Chr 12: 93.57 – 93.58 Mb Chr 10: 95.22 – 95.25 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.^[8] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.^[7][9]

Interactions

SOCS2 has been shown to interact with insulin-like growth factor 1 receptor^[8] and erythropoietin receptor.^[10] Additionally, it acts as a substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex.^[11] It is under investigation for use in targeted protein degradation.^[12]