SOCS4

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.^[5]

SOCS4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IZV
Identifiers
Aliases	SOCS4, SOCS7, suppressor of cytokine signaling 4
External IDs	OMIM: 616337; MGI: 1914546; HomoloGene: 15442; GeneCards: SOCS4; OMA:SOCS4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,027,230 bp[1] End 55,049,489 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 47,514,388 bp[2] End 47,533,559 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell tibia visceral pleura parietal pleura tail of epididymis germinal epithelium mucosa of ileum mucosa of paranasal sinus cardiac muscle tissue of right atrium tibialis anterior muscle Top expressed in medial ganglionic eminence conjunctival fornix vestibular membrane of cochlear duct epithelium of small intestine carotid body atrioventricular valve lymph node trigeminal ganglion lumbar spinal ganglion hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase inhibitor activity protein binding Cellular component cytoplasm intracellular anatomical structure Biological process negative regulation of epidermal growth factor-activated receptor activity regulation of growth negative regulation of signal transduction intracellular signal transduction positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 122809 67296 Ensembl ENSG00000180008 ENSMUSG00000048379 UniProt Q8WXH5 Q91ZA6 RefSeq (mRNA) NM_080867 NM_199421 NM_080843 RefSeq (protein) NP_543143 NP_955453 NP_543119 Location (UCSC) Chr 14: 55.03 – 55.05 Mb Chr 14: 47.51 – 47.53 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.