SOCS5

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.^[5][6][7]

SOCS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N34
Identifiers
Aliases	SOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDs	OMIM: 607094; MGI: 2385459; HomoloGene: 10495; GeneCards: SOCS5; OMA:SOCS5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 46,698,952 bp[1] End 46,780,245 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 87,415,107 bp[2] End 87,445,267 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm buccal mucosa cell endothelial cell germinal epithelium lactiferous duct parietal pleura saphenous vein cerebellar vermis stromal cell of endometrium Epithelium of choroid plexus Top expressed in substantia nigra ventromedial nucleus anterior amygdaloid area nucleus accumbens lateral septal nucleus olfactory tubercle mammillary body globus pallidus lateral hypothalamus subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function epidermal growth factor receptor binding protein kinase inhibitor activity receptor tyrosine kinase binding protein binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm cytosol phosphatidylinositol 3-kinase complex Biological process receptor signaling pathway via JAK-STAT intracellular signal transduction epidermal growth factor receptor signaling pathway negative regulation of epidermal growth factor-activated receptor activity cell growth protein ubiquitination regulation of growth positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of receptor signaling pathway via JAK-STAT negative regulation of T-helper 2 cell differentiation positive regulation of T-helper 1 cell differentiation negative regulation of signal transduction negative regulation of interleukin-6 production negative regulation of inflammatory response cellular response to low-density lipoprotein particle stimulus negative regulation of monocyte chemotactic protein-1 production vascular endothelial cell response to fluid shear stress post-translational protein modification cytokine-mediated signaling pathway regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9655 56468 Ensembl ENSG00000171150 ENSMUSG00000037104 UniProt O75159 O54928 RefSeq (mRNA) NM_144949 NM_014011 NM_019654 RefSeq (protein) NP_054730 NP_659198 NP_062628 Location (UCSC) Chr 2: 46.7 – 46.78 Mb Chr 17: 87.42 – 87.45 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.^[7]