SOCS7

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.^[5][6][7]

SOCS7
Identifiers
Aliases	SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7
External IDs	OMIM: 608788; MGI: 2651588; HomoloGene: 16331; GeneCards: SOCS7; OMA:SOCS7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,351,844 bp[1] End 38,405,593 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 97,253,261 bp[2] End 97,289,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis Cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum ganglionic eminence sural nerve islet of Langerhans skeletal muscle tissue Top expressed in seminiferous tubule Rostral migratory stream secondary oocyte zygote primary oocyte neural layer of retina cerebellar vermis nucleus of stria terminalis lobe of cerebellum epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein kinase inhibitor activity protein binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component plasma membrane membrane nucleus cytoplasm cytosol phosphatidylinositol 3-kinase complex Biological process insulin receptor signaling pathway regulation of growth negative regulation of signal transduction intracellular signal transduction cerebral cortex radially oriented cell migration layer formation in cerebral cortex fat cell differentiation protein ubiquitination negative regulation of protein kinase activity cytokine-mediated signaling pathway radial glia guided migration of Purkinje cell negative regulation of receptor signaling pathway via JAK-STAT biological process regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30837 192157 Ensembl ENSG00000274229 ENSG00000274211 ENSMUSG00000038485 UniProt O14512 Q8VHQ2 RefSeq (mRNA) NM_014598 NM_138657 RefSeq (protein) NP_055413 NP_619598 Location (UCSC) Chr 17: 38.35 – 38.41 Mb Chr 11: 97.25 – 97.29 Mb PubMed search [3] [4]
Wikidata
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Interactions

SOCS7 has been shown to interact with NCK1.^[5]