SOD3

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.

SOD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JLP
Identifiers
Aliases	SOD3, EC-SOD, superoxide dismutase 3, extracellular, superoxide dismutase 3
External IDs	OMIM: 185490; MGI: 103181; HomoloGene: 2334; GeneCards: SOD3; OMA:SOD3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 24,789,912 bp[1] End 24,800,842 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 27.92 cM Start 52,521,133 bp[2] End 52,528,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta right uterine tube ascending aorta right coronary artery popliteal artery tibial arteries left coronary artery gastric mucosa canal of the cervix right lung Top expressed in choroid plexus of fourth ventricle ascending aorta right kidney aortic valve lactiferous gland human kidney right lung brown adipose tissue adrenal gland ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding zinc ion binding metal ion binding antioxidant activity protein binding oxidoreductase activity copper ion binding superoxide dismutase activity superoxide dismutase copper chaperone activity Cellular component cytoplasm extracellular matrix Golgi lumen extracellular exosome nucleus extracellular space extracellular region collagen-containing extracellular matrix Biological process response to hypoxia response to copper ion response to oxidative stress superoxide metabolic process cellular response to oxidative stress removal of superoxide radicals cellular oxidant detoxification positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6649 20657 Ensembl ENSG00000109610 ENSMUSG00000072941 UniProt P08294 O09164 RefSeq (mRNA) NM_003102 NM_011435 RefSeq (protein) NP_003093 NP_035565 Location (UCSC) Chr 4: 24.79 – 24.8 Mb Chr 5: 52.52 – 52.53 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.^[5]

Among black garden ants (Lasius niger), the lifespan of queens is an order of magnitude greater than that of workers despite no systematic nucleotide sequence difference between them.^[6] The SOD3 gene was found to be the most differentially over-expressed gene in the brains of queen vs worker ants. This finding raises the possibility that SOD3 antioxidant activity plays a key role in the striking longevity of social insect queens.^[6]