SOSTDC1

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.^[5]

SOSTDC1
Identifiers
Aliases	SOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDs	OMIM: 609675; MGI: 1913292; HomoloGene: 9154; GeneCards: SOSTDC1; OMA:SOSTDC1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.2 Start 16,461,481 bp[1] End 16,530,580 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A3 Start 36,364,138 bp[2] End 36,368,451 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium hair follicle Epithelium of choroid plexus parotid gland skin of thigh skin of arm lower lobe of lung rectum sperm endothelial cell Top expressed in Epithelium of choroid plexus molar retinal pigment epithelium lumbar spinal ganglion sciatic nerve lip right kidney lateral recess human kidney Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function BMP binding BMP receptor activity Cellular component extracellular region extracellular space Biological process pattern specification process odontogenesis of dentin-containing tooth hair follicle morphogenesis mammary gland bud morphogenesis negative regulation of cell fate commitment Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway BMP signaling pathway negative regulation of BMP signaling pathway negative regulation of myoblast differentiation negative regulation of determination of dorsal identity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25928 66042 Ensembl ENSG00000171243 ENSMUSG00000036169 UniProt Q6X4U4 Q9CQN4 RefSeq (mRNA) NM_015464 NM_025312 RefSeq (protein) NP_056279 NP_079588 Location (UCSC) Chr 7: 16.46 – 16.53 Mb Chr 12: 36.36 – 36.37 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.^[5]

Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.^[6][7][8]