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SOSTDC1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

SOSTDC1
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Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[5]

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Function

This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[5]

Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.[6][7][8]

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References

Further reading

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