SOX14

Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene.^[5][6]

SOX14
Identifiers
Aliases	SOX14, SOX28, SRY-box 14, SRY-box transcription factor 14
External IDs	OMIM: 604747; MGI: 98362; HomoloGene: 31224; GeneCards: SOX14; OMA:SOX14 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 137,764,315 bp[1] End 137,766,334 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.3|9 52.11 cM Start 99,756,159 bp[2] End 99,758,223 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta hypothalamus substantia nigra prostate spinal cord C1 segment Top expressed in urethra male urethra embryo embryo mesencephalon genital tubercle epiblast rhombencephalon cerebellar cortex hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding chromatin binding protein binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cellular component Biological process regulation of neuron migration negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development visual perception entrainment of circadian clock cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8403 20669 Ensembl ENSG00000168875 ENSMUSG00000053747 UniProt O95416 Q04892 RefSeq (mRNA) NM_004189 NM_011440 RefSeq (protein) NP_004180 NP_035570 Location (UCSC) Chr 3: 137.76 – 137.77 Mb Chr 9: 99.76 – 99.76 Mb PubMed search [3] [4]
Wikidata
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Function

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome.^[6]