SOX21

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.^[5][6] It is a member of the Sox gene family of transcription factors.

SOX21
Identifiers
Aliases	SOX21, SOX25, SRY-box 21, SRY-box transcription factor 21
External IDs	OMIM: 604974; MGI: 2654070; HomoloGene: 5143; GeneCards: SOX21; OMA:SOX21 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.1 Start 94,709,622 bp[1] End 94,712,545 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 118,470,644 bp[2] End 118,474,442 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence skin of leg skin of abdomen amygdala caudate nucleus mucosa of esophagus putamen nucleus accumbens cingulate gyrus Top expressed in saccule hair follicle molar otic placode otic vesicle epithelium of stomach ventricular zone medial ganglionic eminence pyloric antrum lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cellular component Biological process hair follicle development regulation of transcription by RNA polymerase II hair cycle regulation of transcription, DNA-templated transcription, DNA-templated stem cell differentiation skin development transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II cell differentiation central nervous system development neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11166 223227 Ensembl ENSG00000125285 ENSMUSG00000061517 UniProt Q9Y651 Q811W0 RefSeq (mRNA) NM_007084 NM_177753 RefSeq (protein) NP_009015 NP_808421 Location (UCSC) Chr 13: 94.71 – 94.71 Mb Chr 14: 118.47 – 118.47 Mb PubMed search [3] [4]
Wikidata
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Function

In the chick embryo, Sox21 promotes neuronal cellular differentiation by counteracting the activity of Sox1, Sox2, and Sox3, which maintain neural cells in an undifferentiated state.^[7]

SOX21 knockout mice display hair loss beginning from postnatal day 11. New hair regrowth was initiated a few days later but was followed by renewed hair loss. Sox21 is also expressed in the hair shaft cuticle in humans and consequently variants of the Sox21 gene could be responsible for some hair loss conditions in humans. ^[8]

See also

• SOX genes