SPACA3

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.^[5][6]

SPACA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YF2
Identifiers
Aliases	SPACA3, 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDs	OMIM: 612749; MGI: 1922872; HomoloGene: 18365; GeneCards: SPACA3; OMA:SPACA3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 32,970,376 bp[1] End 32,997,877 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 80,749,191 bp[2] End 80,758,640 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle body of pancreas gonad mucosa of transverse colon right coronary artery tibial nerve granulocyte Top expressed in spermatid seminiferous tubule spermatocyte lacrimal gland morula pancreas cochlea islet of Langerhans foregut stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lysozyme activity Cellular component integral component of membrane extracellular region acrosomal vesicle secretory granule membrane cytoplasmic vesicle extracellular space acrosomal membrane acrosomal matrix Biological process monocyte activation cell wall macromolecule catabolic process fertilization positive regulation of phagocytosis response to virus positive regulation of macrophage activation sperm-egg recognition defense response to Gram-positive bacterium peptidoglycan catabolic process defense response to Gram-negative bacterium fusion of sperm to egg plasma membrane involved in single fertilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124912 75622 Ensembl ENSG00000141316 ENSMUSG00000053184 UniProt Q8IXA5 Q9D9X8 RefSeq (mRNA) NM_173847 NM_001317225 NM_001317226 NM_029367 NM_001359183 RefSeq (protein) NP_001304154 NP_001304155 NP_776246 NP_083643 NP_001346112 Location (UCSC) Chr 17: 32.97 – 33 Mb Chr 11: 80.75 – 80.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Acrosome