SPARCL1

SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC.^[5][6]

SPARCL1
Identifiers
Aliases	SPARCL1, MAST 9, MAST9, PIG33, SC1, SPARC like 1
External IDs	OMIM: 606041; MGI: 108110; HomoloGene: 3438; GeneCards: SPARCL1; OMA:SPARCL1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 87,473,335 bp[1] End 87,531,061 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E5|5 50.55 cM Start 104,226,977 bp[2] End 104,261,599 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus postcentral gyrus superior frontal gyrus Brodmann area 23 orbitofrontal cortex external globus pallidus Region I of hippocampus proper occipital lobe Brodmann area 46 primary visual cortex Top expressed in deep cerebellar nuclei dorsal tegmental nucleus medial vestibular nucleus cerebellar vermis ventral tegmental area globus pallidus pontine nuclei dorsomedial hypothalamic nucleus lobe of cerebellum paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding collagen binding extracellular matrix binding protein binding Cellular component extracellular exosome extracellular space endoplasmic reticulum lumen extracellular region collagen-containing extracellular matrix glutamatergic synapse Biological process signal transduction anatomical structure development post-translational protein modification synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8404 13602 Ensembl ENSG00000152583 ENSMUSG00000029309 UniProt Q14515 P70663 RefSeq (mRNA) NM_004684 NM_001128310 NM_001291976 NM_001291977 NM_010097 NM_001359014 NM_001359016 RefSeq (protein) NP_001121782 NP_001278905 NP_001278906 NP_004675 NP_034227 NP_001345943 NP_001345945 Location (UCSC) Chr 4: 87.47 – 87.53 Mb Chr 5: 104.23 – 104.26 Mb PubMed search [3] [4]
Wikidata
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Biology

It interacts with the extracellular matrix to create intermediate states of cell adhesion.^[7] Due to its dynamic extracellular roles, it is implicated in cancer metastasis and inflammation and it is considered a matricellular protein.^[8][9] In humans hevin is encoded by the SPARCL1 gene.^[10][11] Hevin is produced by astrocytes. It is involved in synapse formation, function, plasticity, and elimination as well as brain chemistry regulation.^[12]

Interactions

• CALY (calcyon)^[13]

See also

• Thrombospondin
• Tenascin