SPDEF

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.^[5][6][7]

SPDEF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DKX
Identifiers
Aliases	SPDEF, PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
External IDs	OMIM: 608144; MGI: 1353422; HomoloGene: 8231; GeneCards: SPDEF; OMA:SPDEF - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 34,537,802 bp[1] End 34,556,333 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 27,933,326 bp[2] End 27,947,929 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland nasal epithelium mucosa of transverse colon prostate mucosa of ileum olfactory zone of nasal mucosa buccal mucosa cell trachea mucosa of sigmoid colon lactiferous duct Top expressed in crypt of lieberkuhn of small intestine gastric mucosa epithelium of stomach mucous cell of stomach pyloric antrum Paneth cell parotid gland duodenum female urethra seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of cell fate commitment lung goblet cell differentiation intestinal epithelial cell development transcription, DNA-templated positive regulation of cell fate commitment positive regulation of transcription by RNA polymerase II positive regulation of apoptotic process regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25803 30051 Ensembl ENSG00000124664 ENSMUSG00000024215 UniProt O95238 Q9WTP3 RefSeq (mRNA) NM_001252294 NM_012391 NM_013891 NM_001357728 RefSeq (protein) NP_001239223 NP_036523 NP_038919 NP_001344657 Location (UCSC) Chr 6: 34.54 – 34.56 Mb Chr 17: 27.93 – 27.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]^[7]

Interactions

SPDEF has been shown to interact with NKX3-1.^[8]