SPINK1

Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.^[5]

SPINK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CGI, 1CGJ, 1HPT
Identifiers
Aliases	SPINK1, PCTT, PSTI, Spink3, TATI, TCP, serine peptidase inhibitor, Kazal type 1, serine peptidase inhibitor Kazal type 1
External IDs	OMIM: 167790; MGI: 106202; HomoloGene: 68300; GeneCards: SPINK1; OMA:SPINK1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 147,824,572 bp[1] End 147,831,671 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 43,861,147 bp[2] End 43,870,622 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans pancreatic ductal cell beta cell duodenum jejunal mucosa rectum mucosa of transverse colon mucosa of sigmoid colon pylorus Top expressed in seminal vesicula intestinal villus epithelium of small intestine ileum right kidney left colon human kidney pyloric antrum jejunum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component extracellular region acrosomal vesicle extracellular exosome extracellular space Biological process negative regulation of nitric oxide mediated signal transduction regulation of acrosome reaction negative regulation of peptidase activity negative regulation of peptidyl-tyrosine phosphorylation negative regulation of serine-type endopeptidase activity regulation of store-operated calcium entry negative regulation of calcium ion import sperm capacitation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6690 20730 Ensembl ENSG00000164266 ENSMUSG00000024503 UniProt P00995 P09036 RefSeq (mRNA) NM_003122 NM_001354966 NM_001379610 NM_009258 RefSeq (protein) NP_003113 NP_001341895 NP_001366539 NP_033284 Location (UCSC) Chr 5: 147.82 – 147.83 Mb Chr 18: 43.86 – 43.87 Mb PubMed search [3] [4]
Wikidata
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Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.^[6]

It has also been associated with prostate cancer.^[7]

See also

• Kazal-type serine protease inhibitor domain
• Pancreatitis