SPINT2

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.^[5][6][7] SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

SPINT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4U32
Identifiers
Aliases	SPINT2, DIAR3, HAI-2, HAI2, Kop, PB, serine peptidase inhibitor, Kunitz type, 2, serine peptidase inhibitor, Kunitz type 2
External IDs	OMIM: 605124; MGI: 1338031; HomoloGene: 7955; GeneCards: SPINT2; OMA:SPINT2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,244,035 bp[1] End 38,292,615 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 28,955,748 bp[2] End 28,981,337 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell mucosa of transverse colon parotid gland pituitary gland anterior pituitary olfactory zone of nasal mucosa left lobe of thyroid gland right lobe of thyroid gland right uterine tube right testis Top expressed in left colon submandibular gland intestinal villus crypt of lieberkuhn of small intestine pyloric antrum duodenum parotid gland ileum right kidney epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding Cellular component cytoplasm integral component of membrane extracellular region membrane plasma membrane Biological process negative regulation of cell motility negative regulation of peptidase activity negative regulation of cell-cell adhesion establishment or maintenance of cell polarity negative regulation of neural precursor cell proliferation neural tube closure negative regulation of endopeptidase activity epithelial cell morphogenesis involved in placental branching cellular response to BMP stimulus basement membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10653 20733 Ensembl ENSG00000167642 ENSMUSG00000074227 UniProt O43291 Q9WU03 RefSeq (mRNA) NM_021102 NM_001166103 NM_001082548 NM_011464 RefSeq (protein) NP_001159575 NP_066925 NP_001076017 NP_035594 Location (UCSC) Chr 19: 38.24 – 38.29 Mb Chr 7: 28.96 – 28.98 Mb PubMed search [3] [4]
Wikidata
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