SPNS2

Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene.^[5]

SPNS2
Identifiers
Aliases	SPNS2, sphingolipid transporter 2, SLC62A2, DFNB115, SLC63A2
External IDs	OMIM: 612584; MGI: 2384936; HomoloGene: 71040; GeneCards: SPNS2; OMA:SPNS2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,498,881 bp[1] End 4,539,035 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,342,464 bp[2] End 72,380,730 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx C1 segment skin of arm buccal mucosa cell renal medulla right lung inferior ganglion of vagus nerve right frontal lobe upper lobe of left lung Brodmann area 9 Top expressed in esophagus lip muscle of thigh triceps brachii muscle gastrocnemius muscle sternocleidomastoid muscle temporal muscle knee joint mesenteric lymph nodes medial head of gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function sphingolipid transporter activity Cellular component integral component of membrane vesicle lysosomal membrane membrane Biological process lymphocyte homeostasis regulation of humoral immune response regulation of eye pigmentation lipid transport lymph node development B cell homeostasis bone development lymphocyte migration locomotion transmembrane transport sphingosine-1-phosphate receptor signaling pathway sphingolipid metabolic process T cell homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124976 216892 Ensembl ENSG00000183018 ENSMUSG00000040447 UniProt Q8IVW8 Q91VM4 RefSeq (mRNA) NM_001124758 NM_001276383 NM_153060 RefSeq (protein) NP_001118230 NP_001263312 NP_694700 Location (UCSC) Chr 17: 4.5 – 4.54 Mb Chr 11: 72.34 – 72.38 Mb PubMed search [3] [4]
Wikidata
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Model organisms

The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular development, and human SPNS2 can transport S1P analogues, including the immunomodulating drug FTY720-P.^[6][7]