SPOCK2

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.^[5][6]

SPOCK2
Identifiers
Aliases	SPOCK2, testican-2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
External IDs	OMIM: 607988; MGI: 1891351; HomoloGene: 8854; GeneCards: SPOCK2; OMA:SPOCK2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 72,059,034 bp[1] End 72,089,032 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 59,942,041 bp[2] End 59,971,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum lateral nuclear group of thalamus right hemisphere of cerebellum Brodmann area 10 spinal ganglia cerebellar vermis middle frontal gyrus dorsal motor nucleus of vagus nerve pars compacta superior vestibular nucleus Top expressed in habenula entorhinal cortex dorsomedial hypothalamic nucleus perirhinal cortex superior colliculus CA3 field medial dorsal nucleus central gray substance of midbrain subiculum dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding glycosaminoglycan binding extracellular matrix binding metalloendopeptidase inhibitor activity collagen binding Cellular component extracellular region extracellular matrix extracellular space Biological process regulation of cell differentiation synapse assembly peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix organization signal transduction positive regulation of cell-substrate adhesion negative regulation of endopeptidase activity positive regulation of cell motility cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9806 94214 Ensembl ENSG00000107742 ENSMUSG00000058297 UniProt Q92563 Q9ER58 RefSeq (mRNA) NM_001134434 NM_001244950 NM_014767 NM_052994 RefSeq (protein) NP_001127906 NP_001231879 NP_055582 NP_443720 Location (UCSC) Chr 10: 72.06 – 72.09 Mb Chr 10: 59.94 – 59.97 Mb PubMed search [3] [4]
Wikidata
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Function

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM]^[6]