SPOP

For the animated series, see She-Ra: Princess of Power and She-Ra and the Princesses of Power.

For the Singaporean singing competition, see SPOP Sing! (season 1) and SPOP Wave.

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.^[5][6][7]

SPOP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CR2, 3HQH, 3HQI, 3HQL, 3HQM, 3HTM, 3HU6, 3IVB, 3IVQ, 3IVV, 4EOZ, 4HS2, 4J8Z, 4O1V
Identifiers
Aliases	SPOP, BTBD32, TEF2, speckle type BTB/POZ protein, NEDMIDF, NSDVS1, NSDVS2, NEDMACE
External IDs	OMIM: 602650; MGI: 1343085; HomoloGene: 68354; GeneCards: SPOP; OMA:SPOP - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 49,598,884 bp[1] End 49,678,163 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.01 cM Start 95,304,906 bp[2] End 95,384,232 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple muscle layer of sigmoid colon saphenous vein pylorus seminal vesicula popliteal artery tibial arteries urethra cardia smooth muscle tissue Top expressed in temporal muscle triceps brachii muscle cerebellar vermis ankle lobe of cerebellum sternocleidomastoid muscle neural layer of retina digastric muscle parotid gland blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component Cul3-RING ubiquitin ligase complex nuclear speck nucleus nucleoplasm cytoplasm SCF ubiquitin ligase complex Biological process protein ubiquitination regulation of proteolysis negative regulation of transcription by RNA polymerase II glucose homeostasis proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of DNA-binding transcription factor activity positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of type B pancreatic cell apoptotic process ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8405 20747 Ensembl ENSG00000121067 ENSMUSG00000057522 UniProt O43791 Q6ZWS8 RefSeq (mRNA) NM_001007226 NM_001007227 NM_001007228 NM_001007229 NM_001007230 NM_003563 NM_001370730 NM_001370731 NM_001370732 NM_025287 NM_001359107 RefSeq (protein) NP_001007227 NP_001007228 NP_001007229 NP_001007230 NP_001007231 NP_003554 NP_001357659 NP_001357660 NP_001357661 NP_079563 NP_001346036 Location (UCSC) Chr 17: 49.6 – 49.68 Mb Chr 11: 95.3 – 95.38 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.^[7]

DNA repair

The spop gene is the gene most commonly point mutated in human primary prostate cancers.^[8] SPOP protein is essential for the repair of DNA-protein crosslinks by removing topoisomerase 2A from the topoisomerase2A-DNA cleavage complex formed during repair.^[8]

Clinical relevance

Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers.^[9][10]