SPRY1

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.^[5][6][7]

SPRY1
Identifiers
Aliases	SPRY1, hsprouty RTK signaling antagonist 1
External IDs	OMIM: 602465; MGI: 1345139; HomoloGene: 4266; GeneCards: SPRY1; OMA:SPRY1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q28.1 Start 123,396,795 bp[1] End 123,403,760 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 37,694,096 bp[2] End 37,698,747 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium vena cava gallbladder parietal pleura epithelium of colon subcutaneous adipose tissue canal of the cervix skin of leg left uterine tube left lobe of thyroid gland Top expressed in secondary oocyte tail of embryo lip primary oocyte lung esophagus quadriceps femoris muscle right kidney zone of skin adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi apparatus membrane plasma membrane nucleoplasm cytoplasm cytosol Biological process ureteric bud development negative regulation of neurotrophin TRK receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway organ induction bud elongation involved in lung branching negative regulation of Ras protein signal transduction multicellular organism development negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of GTPase activity regulation of signal transduction negative regulation of MAP kinase activity establishment of mitotic spindle orientation metanephros development negative regulation of cell population proliferation negative regulation of ERK1 and ERK2 cascade epithelial to mesenchymal transition involved in cardiac fibroblast development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10252 24063 Ensembl ENSG00000164056 ENSMUSG00000037211 UniProt O43609 Q9QXV9 RefSeq (mRNA) NM_001258038 NM_001258039 NM_005841 NM_199327 NM_001375410 NM_011896 NM_001305440 NM_001305441 NM_001305442 RefSeq (protein) NP_001244967 NP_001244968 NP_005832 NP_955359 NP_001362339 NP_001292369 NP_001292370 NP_001292371 NP_036026 Location (UCSC) Chr 4: 123.4 – 123.4 Mb Chr 3: 37.69 – 37.7 Mb PubMed search [3] [4]
Wikidata
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See also

• Neurofibromin 1
• SPRED1