SPRY4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

SPRY4

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[5][6]

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SPRY4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPRY4, HH17, sprouty RTK signaling antagonist 4
External IDsOMIM: 607984; MGI: 1345144; HomoloGene: 8042; GeneCards: SPRY4; OMA:SPRY4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127496
NM_001293289
NM_001293290
NM_030964

NM_011898

RefSeq (protein)

NP_001120968
NP_001280218
NP_001280219
NP_112226

NP_036028

Location (UCSC)Chr 5: 142.31 – 142.33 MbChr 18: 38.72 – 38.73 Mb
PubMed search[3][4]
Wikidata
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Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[6]

Interactions

SPRY4 has been shown to interact with TESK1.[7]

See also

References

Further reading

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