SRI-42127

SRI-42127 is an experimental drug which acts to inhibit translocation of the RNA-binding HuR protein. HuR translocation promotes the production of inflammatory cytokines in glial cells, and inhibiting HuR has applications both in the treatment of some forms of cancer, and also neuropathic pain.^[1][2][3]

SRI-42127

Identifiers
IUPAC name 3-(1H-indazol-6-yl)-N-methyl-N-(oxan-4-yl)imidazo[1,2-b]pyridazin-6-amine
CAS Number	2727872-68-4
PubChem CID	163415849
ChemSpider	128921334
Chemical and physical data
Formula	C19H20N6O
Molar mass	348.410 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C1CCOCC1)C2=NN3C(=NC=C3C4=CC5=C(C=C4)C=NN5)C=C2
InChI InChI=1S/C19H20N6O/c1-24(15-6-8-26-9-7-15)19-5-4-18-20-12-17(25(18)23-19)13-2-3-14-11-21-22-16(14)10-13/h2-5,10-12,15H,6-9H2,1H3,(H,21,22) Key:AEHZEVSNZUVPNR-UHFFFAOYSA-N

See also

• CMLD-2
• KH-3