SRI (gene)

Sorcin is a protein that in humans is encoded by the SRI gene.^[5][6]

SRI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JUO, 2JC2, 4U8D, 4UPG, 4USL
Identifiers
Aliases	SRI, CP-22, CP22, SCN, V19, sorcin
External IDs	OMIM: 182520; MGI: 98419; HomoloGene: 37736; GeneCards: SRI; OMA:SRI - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.12 Start 88,205,115 bp[1] End 88,226,993 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 3.38 cM Start 8,096,078 bp[2] End 8,119,379 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of sigmoid colon rectum bronchial epithelial cell mucosa of ileum ventricular zone oocyte secondary oocyte right uterine tube nucleus accumbens Top expressed in granulocyte left colon mucous cell of stomach duodenum pyloric antrum Paneth cell endocardial cushion epithelium of stomach decidua right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transmembrane transporter binding calcium channel regulator activity metal ion binding calcium-dependent cysteine-type endopeptidase activity protease binding protein binding protein heterodimerization activity identical protein binding signaling receptor binding Cellular component axon terminus dendritic spine neck vesicle cytosol endoplasmic reticulum membrane membrane T-tubule plasma membrane intracellular anatomical structure sarcoplasmic reticulum nucleoplasm smooth endoplasmic reticulum axon chromaffin granule membrane Z discdkac mitochondrion sarcoplasmic reticulum membrane extracellular exosome cytoplasm Biological process regulation of calcium ion transport regulation of heart contraction cytoplasmic sequestering of transcription factor muscle organ development positive regulation of release of sequestered calcium ion into cytosol negative regulation of heart rate proteolysis negative regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell contraction heart development intracellular sequestering of iron ion regulation of striated muscle contraction negative regulation of transcription regulatory region DNA binding regulation of high voltage-gated calcium channel activity action potential positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell communication by electrical coupling regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of muscle regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium ion transport signal transduction negative regulation of cardiac muscle contraction transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6717 109552 Ensembl ENSG00000075142 ENSMUSG00000003161 UniProt P30626 Q6P069 RefSeq (mRNA) NM_001256891 NM_001256892 NM_003130 NM_198901 NM_001080974 NM_025618 RefSeq (protein) NP_001243820 NP_001243821 NP_003121 NP_944490 NP_001074443 NP_079894 Location (UCSC) Chr 7: 88.21 – 88.23 Mb Chr 5: 8.1 – 8.12 Mb PubMed search [3] [4]
Wikidata
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Interactions

SRI (gene) has been shown to interact with Ryanodine receptor 2,^[7] ANXA7^[8] and GCA.^[9]