SSR2

Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene.^[5][6]

SSR2
Identifiers
Aliases	SSR2, TLAP, TRAP-BETA, TRAPB, HSD25, signal sequence receptor subunit 2
External IDs	OMIM: 600867; MGI: 1913506; HomoloGene: 2369; GeneCards: SSR2; OMA:SSR2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,009,048 bp[1] End 156,020,951 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,575,876 bp[2] End 88,588,419 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans stromal cell of endometrium ganglionic eminence canal of the cervix left adrenal gland left ovary granulocyte left adrenal cortex right adrenal gland Top expressed in yolk sac tail of embryo genital tubercle seminal vesicula lip molar islet of Langerhans embryo spermatocyte efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process cotranslational protein targeting to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6746 66256 Ensembl ENSG00000163479 ENSMUSG00000041355 UniProt P43308 Q9CPW5 RefSeq (mRNA) NM_003145 NM_025448 RefSeq (protein) NP_003136 NP_079724 NP_001343245 NP_001343246 NP_001343247 NP_001343248 Location (UCSC) Chr 1: 156.01 – 156.02 Mb Chr 3: 88.58 – 88.59 Mb PubMed search [3] [4]
Wikidata
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Function

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.^[6]