Somatostatin receptor 1

Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene.^[5][6]

SSTR1
Identifiers
Aliases	SSTR1, SRIF-2, SS-1-R, SS1-R, SS1R, Somatostatin receptor 1
External IDs	OMIM: 182451; MGI: 98327; HomoloGene: 820; GeneCards: SSTR1; OMA:SSTR1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.1 Start 38,207,904 bp[1] End 38,213,067 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C1|12 25.61 cM Start 58,258,558 bp[2] End 58,261,230 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium jejunal mucosa Brodmann area 46 duodenum prefrontal cortex middle temporal gyrus pars reticulata pars compacta Brodmann area 23 dorsolateral prefrontal cortex Top expressed in dentate gyrus of hippocampal formation granule cell embryo superior frontal gyrus primary visual cortex ventromedial nucleus anterior amygdaloid area primary motor cortex subiculum dorsomedial hypothalamic nucleus arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity neuropeptide binding signal transducer activity somatostatin receptor activity peptide binding Cellular component cytoplasm integral component of membrane membrane plasma membrane neuron projection integral component of plasma membrane Biological process glutamate receptor signaling pathway somatostatin signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cellular response to estradiol stimulus cerebellum development spermatogenesis response to starvation forebrain development neuropeptide signaling pathway signal transduction negative regulation of cell population proliferation cellular response to leukemia inhibitory factor G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6751 20605 Ensembl ENSG00000139874 ENSMUSG00000035431 UniProt P30872 P30873 RefSeq (mRNA) NM_001049 NM_009216 RefSeq (protein) NP_001040 NP_033242 Location (UCSC) Chr 14: 38.21 – 38.21 Mb Chr 12: 58.26 – 58.26 Mb PubMed search [3] [4]
Wikidata
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Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.^[6]

See also

• Somatostatin receptor