Somatostatin receptor 4

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.^[5][6]

SSTR4
Identifiers
Aliases	SSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4
External IDs	OMIM: 182454; MGI: 105372; HomoloGene: 20286; GeneCards: SSTR4; OMA:SSTR4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,035,312 bp[1] End 23,039,237 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G3|2 73.44 cM Start 148,237,264 bp[2] End 148,238,687 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus right frontal lobe anterior cingulate cortex cerebellar hemisphere right hemisphere of cerebellum Brodmann area 9 amygdala islet of Langerhans hippocampus proper Top expressed in intestinal villus Ileal epithelium perirhinal cortex entorhinal cortex primary visual cortex dentate gyrus of hippocampal formation granule cell CA3 field superior frontal gyrus granulocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding G protein-coupled receptor activity signal transducer activity somatostatin receptor activity peptide binding Cellular component cytoplasm integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger forebrain development cellular response to glucocorticoid stimulus cell migration arachidonic acid metabolic process positive regulation of MAPK cascade negative regulation of cell population proliferation signal transduction somatostatin signaling pathway chemical synaptic transmission positive regulation of ERK1 and ERK2 cascade positive regulation of arachidonic acid secretion negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6754 20608 Ensembl ENSG00000132671 ENSMUSG00000037014 UniProt P31391 P49660 RefSeq (mRNA) NM_001052 NM_009219 RefSeq (protein) NP_001043 NP_033245 Location (UCSC) Chr 20: 23.04 – 23.04 Mb Chr 2: 148.24 – 148.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.^[6]

See also

• Somatostatin receptor