SSX2

SSX2B
Identifiers
Aliases	SSX2B, CT5.2, CT5.2b, HOM-MEL-40, SSX, synovial sarcoma, X breakpoint 2B, SSX family member 2B
External IDs	HomoloGene: 133226; GeneCards: SSX2B; OMA:SSX2B - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	52,790,305 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right testis; ; left testis; ; sural nerve; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; blood; ; renal cortex; ; human musculoskeletal system;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; transcription corepressor activity; nucleic acid binding;
Cellular component	intracellular anatomical structure; nucleus;
Biological process	negative regulation of nucleic acid-templated transcription; regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	727837
	n/a
	ENSG00000268447
	n/a
	Q16385
	n/a
	NM_001278702; NM_001164417; NM_001278701
	n/a
	NP_001157889; NP_001265630; NP_001265631
	n/a
	Wikidata
View/Edit Human

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.^[3]^[4]

Quick Facts SSX2B, Identifiers ...

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.^[4]

References