SSX2IP

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene.^[5] It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation.^{[6][7][8][9][10]} The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.^[11][12]

SSX2IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T2M, 1XZ9, 2AIN, 2EXG
Identifiers
Aliases	SSX2IP, ADIP, synovial sarcoma, X breakpoint 2 interacting protein, SSX family member 2 interacting protein, hMsd1
External IDs	OMIM: 608690; MGI: 2139150; HomoloGene: 8522; GeneCards: SSX2IP; OMA:SSX2IP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 84,643,706 bp[1] End 84,690,803 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 146,110,397 bp[2] End 146,145,899 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis middle temporal gyrus sperm Brodmann area 23 jejunal mucosa Brodmann area 46 endothelial cell duodenum secondary oocyte Top expressed in Ileal epithelium seminiferous tubule spermatid olfactory epithelium lens spermatocyte fetal liver hematopoietic progenitor cell CA3 field retinal pigment epithelium entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding Cellular component cytoplasm microtubule organizing center adherens junction cell junction cell projection cytoskeleton cell leading edge nucleus ciliary basal body centriolar satellite protein-containing complex Biological process regulation of cell motility intraciliary transport involved in cilium assembly regulation of Rac protein signal transduction cell adhesion cell projection organization cilium assembly centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117178 99167 Ensembl ENSG00000117155 ENSMUSG00000036825 UniProt Q9Y2D8 Q8VC66 RefSeq (mRNA) NM_001166293 NM_001166294 NM_001166295 NM_001166417 NM_014021 NM_001253768 NM_001253769 NM_001253770 NM_138744 NM_001355661 RefSeq (protein) NP_001159765 NP_001159766 NP_001159767 NP_001159889 NP_054740 NP_001240697 NP_001240698 NP_001240699 NP_620083 NP_001342590 Location (UCSC) Chr 1: 84.64 – 84.69 Mb Chr 3: 146.11 – 146.15 Mb PubMed search [3] [4]
Wikidata
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Interactions

SSX2IP has been initially described as a protein to interact with MLLT4^[13] and Actinin, alpha 1.^[13] In the context of centrosome maturation and ciliogenesis it has been shown to interact with WDR8.^[8][9][11]