ST13

This article is about the gene and protein. For the Star Trek 13 film, see Star Trek Beyond. For the ST13 postcode, see ST postcode area.

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.^[5][6][7]

ST13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UZS
Identifiers
Aliases	ST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6, ST13 Hsp70 interacting protein
External IDs	OMIM: 606796; MGI: 1917606; HomoloGene: 2921; GeneCards: ST13; OMA:ST13 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 40,824,535 bp[1] End 40,856,639 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 81,247,870 bp[2] End 81,284,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary Achilles tendon right ovary epithelium of colon ganglionic eminence body of uterus ventricular zone stromal cell of endometrium canal of the cervix gallbladder Top expressed in pineal gland tail of embryo neural layer of retina retinal pigment epithelium yolk sac genital tubercle ventricular zone abdominal wall epiblast dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function dATP binding unfolded protein binding protein-containing complex binding Hsp70 protein binding protein-macromolecule adaptor activity chaperone binding protein binding protein domain specific binding identical protein binding protein dimerization activity Cellular component extracellular exosome cytoplasm cytosol protein-containing complex Biological process protein homooligomerization protein folding negative regulation of protein refolding response to bacterium chaperone cofactor-dependent protein refolding protein homotetramerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6767 70356 Ensembl ENSG00000100380 ENSMUSG00000022403 UniProt P50502 Q99L47 RefSeq (mRNA) NM_003932 NM_001278589 NM_133726 RefSeq (protein) NP_001265518 NP_003923 NP_598487 Location (UCSC) Chr 22: 40.82 – 40.86 Mb Chr 15: 81.25 – 81.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.^[7]