ST6GAL1

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.^[5]

ST6GAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JS1, 4JS2
Identifiers
Aliases	ST6GAL1, SIAT1, ST6GalI, ST6N, ST6 beta-galactoside alpha-2,6-sialyltransferase 1, CDw75
External IDs	OMIM: 109675; MGI: 108470; HomoloGene: 2281; GeneCards: ST6GAL1; OMA:ST6GAL1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.3 Start 186,930,325 bp[1] End 187,078,553 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 14.03 cM Start 23,043,490 bp[2] End 23,179,100 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver renal medulla lymph node bone marrow cells epithelium of nasopharynx nasal epithelium urethra bronchus epithelium of bronchus Top expressed in sciatic nerve utricle iris Rostral migratory stream condyle Paneth cell motor neuron primitive streak left lung lobe facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity protein binding sialyltransferase activity beta-galactoside alpha-2,6-sialyltransferase activity protein homodimerization activity Cellular component integral component of membrane Golgi apparatus membrane Golgi cisterna membrane extracellular region Golgi membrane Biological process sialylation protein glycosylation humoral immune response O-glycan processing oligosaccharide metabolic process N-acetylneuraminate metabolic process protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6480 20440 Ensembl ENSG00000073849 ENSMUSG00000022885 UniProt P15907 Q64685 RefSeq (mRNA) NM_003032 NM_173216 NM_173217 NM_001353916 NM_001252505 NM_001252506 NM_145933 RefSeq (protein) NP_003023 NP_775323 NP_775324 NP_001340845 NP_001239434 NP_001239435 NP_666045 Location (UCSC) Chr 3: 186.93 – 187.08 Mb Chr 16: 23.04 – 23.18 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.^[6]

Transcripts of ST6GAL1 are found in mouse high endothelial cells of mesenteric lymph node and Peyer's patches, and it could be involved in the B cell homing to Peyer's patches.^[7] ST6GAL1 expression has also shown to be upregulated in several types of cancers and has been shown to haves roles in cancer survival and metastasis.^[8]