ST6GALNAC1

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene.^[5] This enzyme adds a N-acetylneuraminic acid (Neu5Ac, a sialic acid) to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.^[6][7]

ST6GALNAC1
Identifiers
Aliases	ST6GALNAC1, HSY11339, SIAT7A, ST6GalNAcI, STYI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
External IDs	OMIM: 610138; MGI: 1341826; HomoloGene: 7937; GeneCards: ST6GALNAC1; OMA:ST6GALNAC1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,624,761 bp[1] End 76,643,786 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 116,655,851 bp[2] End 116,666,333 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon mucosa of ileum rectum nasal epithelium bronchial epithelial cell mucosa of transverse colon olfactory zone of nasal mucosa jejunal mucosa trachea duodenum Top expressed in conjunctival fornix corneal stroma lacrimal gland submandibular gland parotid gland Paneth cell muscle of thigh small intestine ileum central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sialyltransferase activity glycosyltransferase activity alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process sialylation protein glycosylation oligosaccharide biosynthetic process oligosaccharide metabolic process protein N-linked glycosylation via asparagine ganglioside biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55808 20445 Ensembl ENSG00000070526 ENSMUSG00000009588 UniProt Q9NSC7 Q9QZ39 RefSeq (mRNA) NM_001289107 NM_018414 NM_011371 RefSeq (protein) NP_001276036 NP_060884 NP_035501 Location (UCSC) Chr 17: 76.62 – 76.64 Mb Chr 11: 116.66 – 116.67 Mb PubMed search [3] [4]
Wikidata
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See also

• Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase