ST8SIA1

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.^[5][6]

ST8SIA1
Identifiers
Aliases	ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
External IDs	OMIM: 601123; MGI: 106011; HomoloGene: 2282; GeneCards: ST8SIA1; OMA:ST8SIA1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.1 Start 22,063,773 bp[1] End 22,437,041 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G3|6 74.78 cM Start 142,767,271 bp[2] End 142,910,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence Achilles tendon right hemisphere of cerebellum gonad muscle layer of sigmoid colon prefrontal cortex right adrenal cortex C1 segment testicle Top expressed in molar facial motor nucleus medial vestibular nucleus anterior horn of spinal cord deep cerebellar nuclei pontine nuclei dorsal tegmental nucleus substantia nigra proximal tubule habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sialyltransferase activity glycosyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process glycosphingolipid biosynthetic process sialylation protein glycosylation cellular response to heat positive regulation of cell population proliferation sphingolipid metabolic process lipid metabolism carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6489 20449 Ensembl ENSG00000111728 ENSMUSG00000030283 UniProt Q92185 Q64687 RefSeq (mRNA) NM_001304450 NM_003034 NM_011374 RefSeq (protein) NP_001291379 NP_003025 NP_035504 Location (UCSC) Chr 12: 22.06 – 22.44 Mb Chr 6: 142.77 – 142.91 Mb PubMed search [3] [4]
Wikidata
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Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.^[6]

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.^[7]