ST8SIA2

Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene.^[5][6]

ST8SIA2
Identifiers
Aliases	ST8SIA2, HsT19690, SIAT8B, ST8SIA-II, STX, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, SIAT8-B, ST8SiaII
External IDs	OMIM: 602546; MGI: 106020; HomoloGene: 4384; GeneCards: ST8SIA2; OMA:ST8SIA2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 92,393,881 bp[1] End 92,468,728 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D1 Start 73,588,867 bp[2] End 73,663,438 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone testicle left ventricle apex of heart prefrontal cortex retinal pigment epithelium hypothalamus gonad cingulate gyrus Top expressed in Rostral migratory stream internal carotid artery external carotid artery ganglionic eminence medial ganglionic eminence vestibular sensory epithelium epithelium of lens neural tube ventricular zone utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity sialyltransferase activity sialic acid binding alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Cellular component integral component of membrane recycling endosome Golgi apparatus membrane Golgi membrane early endosome Biological process N-glycan processing ganglioside biosynthetic process nervous system development protein glycosylation oligosaccharide metabolic process sialylation carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8128 20450 Ensembl ENSG00000140557 ENSMUSG00000025789 UniProt Q92186 O35696 RefSeq (mRNA) NM_006011 NM_001330416 NM_009181 RefSeq (protein) NP_001317345 NP_006002 NP_006002.1 NP_033207 Location (UCSC) Chr 15: 92.39 – 92.47 Mb Chr 7: 73.59 – 73.66 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.^[6]