ST8SIA4

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.^[5][6]

ST8SIA4
Identifiers
Aliases	ST8SIA4, PST, PST1, SIAT8D, ST8SIA-IV, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
External IDs	OMIM: 602547; MGI: 106018; HomoloGene: 4147; GeneCards: ST8SIA4; OMA:ST8SIA4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q21.1 Start 100,806,933 bp[1] End 100,903,282 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 95,587,682 bp[2] End 95,667,571 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell blood monocyte trabecular bone cartilage tissue visceral pleura granulocyte bone marrow lymph node amniotic fluid Top expressed in fossa median eminence Rostral migratory stream medial ganglionic eminence blood motor neuron substantia nigra suprachiasmatic nucleus superior cervical ganglion supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sialyltransferase activity sialic acid binding glycosyltransferase activity transferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Cellular component integral component of membrane Golgi membrane membrane Golgi apparatus Biological process nervous system development protein glycosylation N-glycan processing ganglioside biosynthetic process oligosaccharide metabolic process sialylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7903 20452 Ensembl ENSG00000113532 ENSMUSG00000040710 UniProt Q92187 Q64692 RefSeq (mRNA) NM_005668 NM_175052 NM_001159745 NM_009183 RefSeq (protein) NP_005659 NP_778222 NP_001153217 NP_033209 Location (UCSC) Chr 5: 100.81 – 100.9 Mb Chr 1: 95.59 – 95.67 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.^[6]